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(2020) Altered expression of a high quality control protease in E. coli reshapes the in vivo mutational landscape of the model enzyme
analysis short article up-to-date Aug five, 2024 The proteasome controls levels of most cellular proteins, and its action is controlled beneath strain, quiescence, and inflammation. nevertheless, variables deciding the proteasomal degradation fee continue to be improperly comprehended. Proteasome substrates are conjugated with small proteins (tags) like ubiquitin and Fat10 to focus on them to the proteasome. it can be unclear In case the structural plasticity of proteasome-targeting tags can impact substrate degradation. Fat10 is upregulated in the course of inflammation, and its substrates endure quick proteasomal degradation. We report which the degradation level of Fat10 substrates critically depends upon the structural plasticity of Fat10. While the ubiquitin tag is recycled on the proteasome, Fat10 is degraded With all the substrate.
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